Effect of IL-8 on airway goblet cell secretion: a role of neutrophil elastase

To determine the effect of the cytokine interleukin-8 (IL-8) on goblet cell secretion and a possible involvement of neutrophil elastase, we studied guinea pig trachea by a semi-quantitative method. Intravenously administered IL-8 decreased mucus score in a dose-dependent manner, indicating an increa...

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Bibliographic Details
Published inEnsho Vol. 14; no. 2; pp. 157 - 158
Main Authors Tamaoki, Jun, Takeyama, Kiyoshi, Tagaya, Etsuko, Chiyotani, Atsushi, Konno, Kimio
Format Journal Article
LanguageJapanese
English
Published The Japanese Society of Inflammation and Regeneration 1994
Subjects
goblet cell
IL-8
neutrophil elastase
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Summary:To determine the effect of the cytokine interleukin-8 (IL-8) on goblet cell secretion and a possible involvement of neutrophil elastase, we studied guinea pig trachea by a semi-quantitative method. Intravenously administered IL-8 decreased mucus score in a dose-dependent manner, indicating an increase in goblet cell secretion. Pretreatment of animals with ONO-5046, a specific inhibitor of neutrophil elastase, dose-dependently inhibited IL-8-induced goblet cell secretion. These results suggest that IL-8 stimulates airway goblet cell secretion and that neutrophil elastase may play a role in this effect.
ISSN:0389-4290
1884-4006
DOI:10.2492/jsir1981.14.157