Monte Carlo simulation of liver cancer treatment with 166Ho-loaded glass microspheres

Microspheres loaded with pure beta-emitter radioisotopes are used in the treatment of some types of liver cancer. The Instituto de Pesquisas Energéticas e Nucleares (IPEN) is developing 166Ho-loaded glass microspheres as an alternative to the commercially available 90Y microspheres. This work descri...

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Published inRadiation physics and chemistry (Oxford, England : 1993) Vol. 95; pp. 185 - 187
Main Authors da Costa Guimarães, Carla, Moralles, Maurício, Roberto Martinelli, José
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.02.2014
Subjects
Brachytherapy
GEANT4
MASH phantom
Microspheres
Monte Carlo
GEANT4
Microspheres
Brachytherapy
Monte Carlo
MASH phantom
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Summary:Microspheres loaded with pure beta-emitter radioisotopes are used in the treatment of some types of liver cancer. The Instituto de Pesquisas Energéticas e Nucleares (IPEN) is developing 166Ho-loaded glass microspheres as an alternative to the commercially available 90Y microspheres. This work describes the implementation of a Monte Carlo code to simulate both the irradiation effects and the imaging of 166Ho and 90Y sources localized in different parts of the liver. Results obtained with the code and perspectives for the future are discussed. ► Monte Carlo simulation of treatments with 166Ho- and 90Y-loaded microspheres. ► A voxelized anthropomorphic phantom and a simplified gamma camera were used. ► Volumetric dose map with 1.2mm resolution was calculated. ► Image of the gamma camera was produced. ► Perspectives of treatment planning using Monte Carlo and GEANT4.
Bibliography:ObjectType-Article-1
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ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2012.12.050