Alterations in serum phospholipid composition in patients on chronic hemodialysis

• Published in: Jinko Toseki Kenkyukai kaishi. [Journal of the Dialysis Research Society Vol. 17; no. 4; pp. 235 - 241
• Main Authors: Iida, Hisaya, Sawada, Shigeki, Ohashi, Hiroshige, Furuta, Akiharu, Abe, Chikashi, Takahashi, Youichi
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society for Dialysis Therapy 1984
• ISSN: 0288-7045; 1884-6203
• DOI: 10.4009/jsdt1968.17.235

It is well documented that the life span of patients on chronic hemodialysis is shortened because of the development of rapid and progressive cardiovascular disease and it has been suggested that abnormalities in serum lipid metabolism are involved in the development of such cardiovascular disorders. In the present study, we determined the phospholipid composition of the serum of 55 patients on chronic hemodialysis, and the following results were obtained: (1) The level of serum triglyceride (TG) was significantly (p<0.01) higher and the concentration of high density lipoprotein cholesterol (HDL-C) was lower (p<0.01) in patients than in normal subjects (n=18). (2) The serum TG level was inversely correlated with HDL-C (r=-0.40, p<0.01), but did not correlate with fasting immunoreactive insulin levels. (3) Analysis of serum phospholipid showed significant increases in lysolecithin (8.2→10. 0%, p<0.05) and sphingomyelin (16.4→18.5%, p<0.01) with a concomitant decrease in lecithin (66.7→63.2%, p<0.01). (4) The level of lysolecithin was found to be higher in patients with more than 10mg of serum creatinine per dl than in those with less than 10mg/dl.