A case of fulminant hepatitis cured with the glucagon-insulin treatment
A 17-year-old male patient with fulminant hepatitis who could be cured with the glucagon-insulin (G-I) treatment is reported. The patient was severely jaundiced (total scrum bilirubin 12.6mg/dl), his serum alanine aminotransferase 828 units, blood ammonia 101μg/dl and both HBs antigen and HBs antibo...
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Published in | Kanzo Vol. 21; no. 10; pp. 1352 - 1357 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | Japanese |
Published |
The Japan Society of Hepatology
1980
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Subjects | |
Online Access | Get full text |
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Summary: | A 17-year-old male patient with fulminant hepatitis who could be cured with the glucagon-insulin (G-I) treatment is reported. The patient was severely jaundiced (total scrum bilirubin 12.6mg/dl), his serum alanine aminotransferase 828 units, blood ammonia 101μg/dl and both HBs antigen and HBs antibody were simultaneously detected with the radioimmunoassay. Intensive parenteral administrations of prednisolone and l-DOPA, combined with rectal applications of lactulose, proved ineffective in preventing from his Grade III (Adams and Foley) hepatic encephalopathy with asterexis. The G-I treatment was therefore started, which resulted in awakening from coma with a decrease of blood ammonia. During the clinical course, serum AFP level was as high as 782ng/ml, and the liver biopsy specimen obtained after recovery showed cirrhosis of the liver. The mechanism by which the G-I treatment favours the fulminant hepatic disorder was discussed. |
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ISSN: | 0451-4203 1881-3593 |
DOI: | 10.2957/kanzo.21.1352 |