GADD45Is Induced in Alzheimer's Disease, and Protects against Apoptosisin Vitro

Expression of the growth arrest DNA damage-inducible protein,GADD45, has recently been reported to be induced by a wide range of stimuli, especially those that produce a high level of base pair damage. We have investigated the expression ofGADD45in brain tissue obtained from patients suffering from...

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Published inNeurobiology of disease Vol. 5; no. 4; pp. 245 - 252
Main Authors Torp, Reidun, Su, Joseph H., Deng, Gangmin, Cotman, Carl W.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.10.1998
Elsevier
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Summary:Expression of the growth arrest DNA damage-inducible protein,GADD45, has recently been reported to be induced by a wide range of stimuli, especially those that produce a high level of base pair damage. We have investigated the expression ofGADD45in brain tissue obtained from patients suffering from Alzheimer's disease (AD). Our results demonstrate that many neurons express theGADD45protein, and that expression of this protein in neurons is associated with expression of the anti-apoptotic proteinBcl-2, and the presence of DNA damage, but not closely associated with tangle-bearing neurons. Additionally, cell lines overexpressing this protein confer resistance to apoptosis induced by DNA damage agent, suggesting that this protein may participate in cell survival mechanisms.
ISSN:0969-9961
1095-953X
DOI:10.1006/nbdi.1998.0201