ABNORMALITIES OF SERUM TRANSAMINASE ACTIVITIES IN HEALTHY BLOOD DONORS

• Published in: Journal of the Japan Society of Blood Transfusion Vol. 31; no. 2; pp. 110 - 116
• Main Authors: Kanda, Yasuo, Namiki, Hironobu, Miyazawa, Hiroko, Kawahira, Hiroshi, Hoshino, Mozumi, Abe, Mao, Ishino, Takiko, Ito, Takeyoshi, Baba, Masumi, Ozaki, Takahiko, Arakawa, Yasuyuki, Amemiya, Yoichi
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Transfusion Medicine and Cell Therapy 1985
• ISSN: 0546-1448; 1883-8383
• DOI: 10.3925/jjtc1958.31.110

The abnormalities of clinical labolatory tests were investigated among 17, 908 blood donors who came to the Department of Blood Transfusion, Nihon University Itabashi Hospital during the period from April 1, 1980 through March 31, 1983. The first check-up showed that abnormal rates of GOT and GPT activities over 40 mIU were 5.0% and that abnormal rate of GPT alone was 5.1 times more than that of GOT alone. Moreover, 10.5% of 270HBs antigen carriers had abnormal GOT and GPT activities. Of 102 patients with abnormal transaminase activities, clinical diagnosis in the secondary check-up included 65 patients (63.7%) with fatty liver associated with obesity and chronic alcoholic intake, 9 patients (8.8%) with chronic hepatitis and the remaining were required further examination for final diagnosis. These results suggest that the occurrence of post-transfusion non-A non-B hepatitis is not always associated with blood from about two third of apparently healthy donors with abnormal transaminase activities, because most of them have metabolic disoder of the liver, not infectious disease.