Orodispersible Tablets: Novel Strategies and future challenges in Drug Delivery

• Published in: Research journal of pharmacy and technology Vol. 12; no. 11; pp. 5575 - 5582
• Main Authors: Malaak, Fady A., Zeid, Khalid Abu, Fouad, Shahinaze A., El-Nabarawi, Mohamed A.
• Format: Journal Article
• Language: English
• Published: Raipur A&V Publications 01.11.2019
• Subjects: Advantages; Bioavailability; Drug delivery systems; Drug dosages; Dysphagia; Erectile dysfunction; FDA approval; Geriatrics; Manufacturing; Metabolism; Mouth; Patient compliance; Pharmaceutical industry; Sugar
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2019.00966.1

[...]another major section of patients can hardly use the oral conventional dosage forms as a result of sudden allergic attacks, motion sickness, nauseous, uncooperative patients and also travellers who might not have an easy water access. [...]oral drug delivery is usually incomplete if the drug is exposed to hepatic first pass effect, which in turn lowers the bioavailability of many drugs. [...]advancement in oral drug delivery systems provided a vast number of technologies including the production of orodispersible tablets (ODTs). [...]ODTs technology has been used successfully in the production of various active pharmaceutical ingredients such as; central nervous system (CNS) stimulants[11], antidepressants[12], anti-inflammatory drugs[13], centrally acting muscle relaxants[14] antihistaminic agents[15,16], antiemetic agents[17], anti-vertigo agents[18], medications for erectile dysfunction[19,20], medications for premature ejaculation[21] and stress hypertension and anxiety agents [22]. [...]rapid drug absorption and enhanced drug bioavailability are achieved. Since the oral cavity is rich in blood supply, ODTs find it as an attractive site for delivery of drugs into the systemic circulation resulting in a rapid onset of action[33], and hence rapid absorption.