Anthraquinone Azo Dye as a Novel Electrochemical Platform for the Simultaneous Detection of Dopamine and Serotonin: Synthesis and Characterization

• Published in: Russian journal of electrochemistry Vol. 60; no. 8; pp. 687 - 698
• Main Authors: Pallavi, K. M., Mamatha, G. P., Shekharagouda, Pampapathi, Krishnamurthy, Chethan
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.08.2024; Springer Nature B.V
• Subjects: Anthraquinone dyes; Azo dyes; Chemical sensors; Chemical synthesis; Chemistry; Chemistry and Materials Science; Dopamine; Electrochemical analysis; Electrochemistry; Electrodes; Glassy carbon; Molecular structure; NMR; Nuclear magnetic resonance; Physical Chemistry; Serotonin; Voltammetry; real sample; serotonin; anthraquinone azo dye; electrochemical sensor; dopamine
• ISSN: 1023-1935; 1608-3342
• DOI: 10.1134/S1023193524700289

A novel electrochemical sensor was designed by using a synthesized anthraquinone azo dye-based glassy carbon electrode was fabricated and used for enhanced selective determination of Dopamine (DA) and serotonin (5-HT) simultaneously at an optimum working potential (0.11 V for DA and 0.27 V for 5-HT). Utilizing spectroscopic techniques like FT-IR, HR-MS, and 1 H-NMR, a synthesized azo dye molecule structure was characterized. Different electrochemical techniques, including cyclic voltammetry (CV) and differential pulse voltammetry (DPV), were employed to study the electrochemical sensing abilities of the modified working electrode. The DA and 5-HT linear response ranges between current intensities and concentration were found to be 0.001–0.055 and 0.01–1.15 µM and the lower limit of detection (LOD) was 1.9 and 4.16 nM respectively. Further demonstrating the constructed electrochemical sensor’s practical application were tests of reproducibility, stability, and real sample analysis with excellent recovery.