Exploratory and Locomotor Activity in Mice Following Selective Lesions of the Hippocampus: Effects of Lesion Site and Open Field Arena Size

The present study showed arena size-dependent effects on the impairment of locomotor activity and rearing after lesions of caudal hippocampus in C57BL/6 mice: intensive high-speed locomotion without intra- and intertrial habituation accompanied by a decreased number of rears and a reduced tortuosity...

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Published inJournal of evolutionary biochemistry and physiology Vol. 59; no. 4; pp. 1112 - 1135
Main Authors Kuptsov, P. A., Deacon, R. M. J., Anokhin, K. V., Pleskacheva, M. G.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.07.2023
Springer Nature B.V
Subjects
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Evolutionary Biology
Experimental Papers
Exploratory behavior
Habituation
Hippocampus
Hyperactivity
Lesions
Life Sciences
Locomotion
Locomotor activity
cytotoxic lesion
septotemporal (longitudinal) axis
exploration
hippocampus
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Summary:The present study showed arena size-dependent effects on the impairment of locomotor activity and rearing after lesions of caudal hippocampus in C57BL/6 mice: intensive high-speed locomotion without intra- and intertrial habituation accompanied by a decreased number of rears and a reduced tortuosity of the route, suggesting significant impairments of exploratory behavior in an unfamiliar large environment. The lesions of the rostral hippocampus resulted in slight hyperactivity in the large arena without impairment of habituation or rearing. The caudal hippocampus is thus crucial for the environment-dependent modifications of exploratory behavior. Changes on exploratory behavior after its lesions are similar to ones following more extensive or complete lesions of the hippocampus.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093023040099