Near-infrared Emissive 1,2-Dioxetane-based Chemiluminescent Probes

• Published in: Chemical research in Chinese universities Vol. 40; no. 5; pp. 806 - 823
• Main Authors: Chen, Yingqi, Budianta, Richard, Ning, Yingying
• Format: Journal Article
• Language: English
• Published: Changchun Jilin University and The Editorial Department of Chemical Research in Chinese Universities 2024; Springer Nature B.V
• Subjects: Analytical Chemistry; Chemical reactions; Chemiluminescence; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Inorganic Chemistry; Medical imaging; Near infrared radiation; Organic Chemistry; Photon absorption; Physical Chemistry; Review; Bioimaging; Chemiluminescence; Dioxetane; Biosensing; Near-infrared
• ISSN: 1005-9040; 2210-3171
• DOI: 10.1007/s40242-024-4166-6

Chemiluminescence, a phenomenon emitting light from chemical reactions rather than photon absorption, has gained significant interest for applications in bioimaging and biosensing due to its high sensitivity and low background interference. Now there is a growing interest in near-infrared (NIR) chemiluminescent probes for improved tissue penetration and reduced autofluorescence. This review summarizes NIR emissive chemiluminescent probes based on 1,2-dioxetane and discusses their chemical structures and applications. Structure modification strategies for red-shifting wavelength and enhancing brightness include incorporating electron-withdrawing groups, designing chemiluminophore-fluorophore cassettes, and exploring alternative chemiluminescent scaffolds. This review aims to inspire the exploration of NIR chemiluminescent probes in disease detection and treatment.