Evaluation of Anti-diabetic Activity of two marketed Herbal Formulations

Conclusion: Though both the test compounds showed the ability to decrease blood glucose level, we feel that the activity of ADD1 is not very significant. Diabetes mellitus (DM) is a metabolic disorder that is distinguished by hyperglycemia resulting from inadequacy of insulin action, insulin secreti...

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Published inResearch journal of pharmacy and technology Vol. 13; no. 2; pp. 664 - 668
Main Authors Mawlieh, Beracah S., Shastry, C. S., Chand, Sharad
Format Journal Article
LanguageEnglish
Published Raipur A&V Publications 01.02.2020
Subjects
Animals
Antidiabetics
Diabetes
Drug dosages
Glucose
Hyperglycemia
Insulin
Laboratories
Particle size
Pharmaceutical sciences
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Summary:Conclusion: Though both the test compounds showed the ability to decrease blood glucose level, we feel that the activity of ADD1 is not very significant. Diabetes mellitus (DM) is a metabolic disorder that is distinguished by hyperglycemia resulting from inadequacy of insulin action, insulin secretion from pancreatic ß cells or a combination of both.1 Chronic hyperglycemia caused by the insufficiency of insulin action leads to abnormalities in the carbohydrate, lipid, and protein metabolism.2 Type-1 (Insulin dependent, deficient) diabetes is an autoimmune disorder, characterized by pancreatic ß cell destruction with an absolute deficiency of insulin.3 Pathogenesis of Type-2 (Insulin resistant and concomitant deficient insulin secretion) diabetes is due to dysregulated glucose homeostasis, impaired insulin secretion and action.4 Main stray of treatment consisted of the plant based preparation for centuries and continues to be relevant in the era of modern medicine. Several animal models have been developed to screen the compounds for anti-diabetic activity.6 Streptozotocin is used for the induction of both insulin dependent (4070mg/kg body weight) and non-insulin dependent diabetes mellitus (30-40mg/kg body weight). Diabetes was then confirmed by measuring the fasting blood glucose level (>300mg/dl) after a period of 48 hours.10 Experimental design:
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2020.00127.4