The Role of Metalloproteinases in the Development of Ischemia-Induced Pathologies of the Blood–Brain Barrier

The blood–brain barrier (BBB) maintains brain homeostasis by regulating the transport of nutrients and macromolecules from the bloodstream. Its integrity is disrupted in a number of pathologies, such as ischemic stroke, neurodegenerative diseases, or inflammation, leading to loss of control over tra...

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Bibliographic Details
Published inJournal of evolutionary biochemistry and physiology Vol. 60; no. 1; pp. 228 - 246
Main Authors Kolyaskin, L. Yu, Shibeko, A. M.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2024
Springer Nature B.V
Subjects
Angiogenesis
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Blood-brain barrier
Edema
Evolutionary Biology
Hemorrhage
Homeostasis
Ischemia
Life Sciences
Macromolecules
Matrix metalloproteinase
Membrane permeability
Metalloproteinase
Neurodegenerative diseases
Permeability
Reviews
matrix metalloproteinase
ischemic stroke
blood–brain barrier
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Summary:The blood–brain barrier (BBB) maintains brain homeostasis by regulating the transport of nutrients and macromolecules from the bloodstream. Its integrity is disrupted in a number of pathologies, such as ischemic stroke, neurodegenerative diseases, or inflammation, leading to loss of control over transport processes from the bloodstream to the brain, which causes hemorrhage, edema, and tissue death. BBB permeability is largely regulated by matrix metalloproteinases, a family of enzymes responsible for blood vessel remodeling, angiogenesis, and a number of other physiological and pathological processes. This review presents data on the structure of BBB and its pathological alterations caused by metalloproteinases, as well as the mechanisms regulating metalloproteinase activity and difficulties associated with studying these processes.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093024010162