Role of LIM Kinase 1 in Dopaminergic and Serotonergic Neurons in Genome Stability, Learning and Memory during Stress Response to Weakening of Earth’s Magnetic Field in Drosophila

The paper continues the cycle of studies on the evolutionary link between the mechanisms of stress response formation and cognitive functions started in 1959 by M.E. Lobashev and V.B. Savvateev. We explore the role of a key neuroplasticity factor LIM kinase 1 (LIMK1) expressed in dopaminergic and se...

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Published inJournal of evolutionary biochemistry and physiology Vol. 58; no. 1; pp. 35 - 44
Main Authors Medvedeva, A. V., Rebrova, A. V., Zalomaeva, E. S., Turaeva, S. K., Nikitina, E. A., Tokmacheva, E. V., Vasileva, S. A., Shchegolev, B. F., Savvateeva-Popova, E. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2022
Springer Nature B.V
Subjects
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Cognitive ability
DNA damage
Dopamine receptors
Drosophila
Evolutionary Biology
Experimental Papers
Genomes
Insects
Learning
Life Sciences
LIM kinase
Magnetic fields
Memory
Neural plasticity
Neurons
Serotonin
Stress response
double-stranded DNA breaks
Earth’s weakend static magnetic field
dopaminergic and serotonergic neurons
learning
memory
LIMK1
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Summary:The paper continues the cycle of studies on the evolutionary link between the mechanisms of stress response formation and cognitive functions started in 1959 by M.E. Lobashev and V.B. Savvateev. We explore the role of a key neuroplasticity factor LIM kinase 1 (LIMK1) expressed in dopaminergic and serotonergic neurons in Drosophila genome stability, as well as learning and memory, both in standard conditions and when an organism exhibits a stress response to Earth’s weakened static magnetic field (WSMF). We demonstrate that a low LIMK1 level promotes learning acquisition, but not the formation of intermediate-term memory; at the same time, stress exposure restores the learning ability and memory formation in the Drosophila strain with an increased LIMK1 content. We identify inter-strain differences in the frequency of DNA double-strand breaks (DSBs) and show an increase in DSBs after the exposure to WSMF. The data obtained reveal the role of dopaminergic and serotonergic neurons not only in cognitive functions, but also as WSMF targets in the development of a stress response.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093022010033