Myogenic differentiation of mesenchymal stem cells for muscle regeneration in urinary tract

• Published in: Chinese medical journal Vol. 126; no. 15; pp. 2952 - 2959
• Main Authors: Yang, Bin, Zheng, Jun-hua, Zhang, Yuan-yuan
• Format: Journal Article
• Language: English
• Published: China Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China 2013; Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101, USA%Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China%Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101, USA
• Subjects: Adult; Cell Differentiation - physiology; Humans; MEDLINE; Mesenchymal Stem Cell Transplantation; Muscles - cytology; Regeneration - physiology; Tissue Engineering; Urinary Bladder - physiology; Urinary Incontinence, Stress - therapy; 再生; 分化; 尿失禁; 干细胞移植; 平滑肌细胞; 肌肉; 间充质干细胞; mesenchymal stem cell; tissue engineering; stress urinary incontinence; regenerative medicine; bladder
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20130508

Objective This article was to review the current status of adult mesenchymal stem cells transplantation for muscle regeneration in urinary tract and propose the future prospect in this field. Data sources The data used in this review were mainly obtained from articles listed in Medline and PubMed （2000- 2013）. The search terms were ＂mesenchymal stem cells＂, ＂bladder＂, ＂stress urinary incontinence＂ and ＂tissue engineering＂. Study selection Articles regarding the adult mesenchymal stem cells for tissue engineering of bladder and stress urinary incontinence were selected and reviewed. Results Adult mesenchymal stem cells had been identified and well characterized in human bone marrow, adipose tissue, skeletal muscle and urine, and demonstrated the capability of differentiating into smooth muscle cells and skeletal muscle ceils under myogenic differentiation conditions in vitro. Multiple preclinicat and clinical studies indicated that adult mesenchymal stem cells could restore and maintain the structure and function of urinary muscle tissues after transplanted, and potentially improve the quality of life in patients. Conclusions Smooth or skeletal myogenic differentiation of mesenchymal stem cells with regenerative medicine technology may provide a novel approach for muscle regeneration and tissue repair in urinary tract. The long-term effect and safety of mesenchymal stem cell transplantation should be further evaluated before this approach becomes widely used in patients.