A Survey of Biochemical Parameters in Fertile Smokers-A Clinical Study

• Published in: Research journal of pharmacy and technology Vol. 11; no. 2; pp. 559 - 563
• Main Authors: Sridharan, TB, Viswapriya, V S, Basak, Moumita, Parameswari, R, Rao, Kamini A
• Format: Journal Article
• Language: English
• Published: Raipur A&V Publications 01.02.2018
• Subjects: Alcohol; Biochemistry; Cigarettes; Copper; Females; In vitro fertilization; Infertility; Metabolism; Motility; Physiology; Plasma; Potassium; Proteins; Smoking; Sperm; Spermatogenesis; Testosterone; Toxicology; Triglycerides
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2018.00104.X

Aspartic acid presents in spermatozoa as arginine-glycine-aspartic acid (RGD) sequence and that antibody to OPN (Osteopontin), a phosphoprotein that contains the RGD sequence, it has the capability to reduce sperm egg binding before fertilization and also in in vitro fertilization [23].Smoking has inimical outcome on sperm motility, viability, DNA fragmentation, seminal Zinc levels and semen reactive oxygen species levels, also in fertile men and it is directly corresponds with cigarette quantity and smoking period [8]. Semen Sample Collection: Semen samples were collected from n=40 fertile smoker subjects in the Andrology Department of BACC Healthcare Private Ltd. All the samples were collected in a sterile container and further semen analysis was done with computer assisted semen analysis (CASA) based on the standard world health organization (WHO) protocols. The current study discusses the effect of various biochemical parameters such as total protein, aspartic acid, triglycerides and metal ions are correlated with semen parameters namely sperm motility, morphology, concentration and head and tail effects. Since the study is done on samples of smokers that are fertile, though the clinical parameters are little varied from the normal levels they still do not affect the semen parameters, which rules the fertility character of a sperm. Aspartic acid plays a major role as an amino acid triad which when binds with zinc helps the binding of sperm with an egg [22]. [...]aspartic acid is essential for fertility and the p-value in table 2 indicates the positive correlation of aspartic acid on the sperm.