Synthesis and Properties of Symmetrical Bis-ureas Containing a 4-(Trifluoromethoxy)phenyl Fragment

A series of N , N ′-disubstituted bis-ureas containing a lipophilic 4-(trifluoromethoxy)phenyl fragment were synthesized in 58–80% yields by reaction of 4-(trifluoromethoxy)phenyl isocyanate with aliphatic diamines. The synthesized compounds are promising as inhibitors of human soluble epoxide hydro...

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Bibliographic Details
Published inRussian journal of organic chemistry Vol. 58; no. 10; pp. 1429 - 1433
Main Authors Kuznetsov, Ya. P., Burmistrov, V. V., Butov, G. M.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.10.2022
Springer Nature
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Diamines
Isocyanates
Organic Chemistry
Physical Sciences
Science & Technology
Ureas
soluble epoxide hydrolase
isocyanate
urea
fluorine
PAIN
RECEPTOR
ANTITUMOR-ACTIVITY
ANTAGONISTS
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Summary:A series of N , N ′-disubstituted bis-ureas containing a lipophilic 4-(trifluoromethoxy)phenyl fragment were synthesized in 58–80% yields by reaction of 4-(trifluoromethoxy)phenyl isocyanate with aliphatic diamines. The synthesized compounds are promising as inhibitors of human soluble epoxide hydrolase.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428022100074