Effect of Hypercapnia and Hypoxia on the Physiology and Metabolism of the Cerebral Endothelium under Ischemic Conditions

The review addresses the role of blood–brain barrier (BBB) dysfunction in neurological pathology, and describes epigenetic and metabolic regulators of its functional activity and structural integrity. It also provides information on the neuroprotective effects of hypoxia and hypercapnia with an asse...

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Bibliographic Details
Published inJournal of evolutionary biochemistry and physiology Vol. 58; no. 3; pp. 769 - 780
Main Author Tregub, P. P.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.05.2022
Springer Nature B.V
Subjects
Animal Physiology
Antioxidants
Biochemistry
Biomedical and Life Sciences
Blood-brain barrier
Drug metabolism
Endothelial cells
Endothelium
Epigenetics
Evolutionary Biology
Hypercapnia
Hypoxia
Ischemia
Life Sciences
Membrane permeability
Neuroprotection
Permeability
Reviews
Structure-function relationships
hypoxia
blood–brain barrier
cerebral endothelium
neuroprotection
hypercapnia
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Summary:The review addresses the role of blood–brain barrier (BBB) dysfunction in neurological pathology, and describes epigenetic and metabolic regulators of its functional activity and structural integrity. It also provides information on the neuroprotective effects of hypoxia and hypercapnia with an assessment of their impact on the functioning of the BBB. In addition, the review provides arguments for the co-administration of drugs, which modulate BBB metabolism and permeability, and hypercapnic hypoxia to achieve a higher neuroprotective efficacy. The provided data demonstrate that there is a significant number of drugs with a high potential to increase neuroprotective efficacy when combined with hypercapnic hypoxia. These drugs include antioxidants, endothelial cell and membrane protectors, JNK inhibitors, and energotropic drugs.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093022030127