Analysis of Rodent Grooming and Its Microstructure in Modern Neurobiological Studies

Grooming is a complex innate animal behavior that can serve as a marker of physiological state of rodents under stress. Here, we analyze the impact of various experimental factors, including genetic, pharmacological and physiological, on self-grooming behavior of laboratory mice and rats. Analyses o...

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Published inJournal of evolutionary biochemistry and physiology Vol. 60; no. 3; pp. 1125 - 1143
Main Authors Apukhtin, K. V., Shevlyakov, A. D., Kotova, M. M., Amikishiev, S. V., Riga, V. D., Volgin, A. D., Kalueff, A. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.05.2024
Springer Nature B.V
Subjects
Animal Physiology
Autism
Biochemistry
Biomedical and Life Sciences
Evolutionary Biology
Genetic analysis
Grooming
Laboratory animals
Life Sciences
Localization
Mental disorders
Obsessive compulsive disorder
Reviews
grooming
rodents
grooming microstructure
central nervous system diseases
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Summary:Grooming is a complex innate animal behavior that can serve as a marker of physiological state of rodents under stress. Here, we analyze the impact of various experimental factors, including genetic, pharmacological and physiological, on self-grooming behavior of laboratory mice and rats. Analyses of grooming behavior assess not only the number and duration of its bouts but also its microstructure, i.e. frequency, sequence, localization, and consistency. Rodent grooming and its microstructure can serve as a sensitive marker for changes in the brain, its response to stress, and predisposition to pathological conditions simulating such human mental disorders as obsessive-compulsive disorder, autism and depression. Studying rodent self-grooming microstructure can provide valuable information about the mechanisms of brain pathogenesis, having multiple translational implications for neuroscience research.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093024030219