Modeling Tauopathies in Zebrafish (Danio rerio)

Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of the tau protein in the brain, which causes clinical dementia. The tau protein stabilizes microtubules and regulates axonal transport, however, when hyper-phosphorylated, it aggregates in the brain. Tauopaties...

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Published inJournal of evolutionary biochemistry and physiology Vol. 59; no. 6; pp. 2055 - 2071
Main Authors Kotova, М. М., Kolesnikova, Т. О., Kalueff, A. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.11.2023
Springer Nature B.V
Subjects
Alzheimer's disease
Animal models
Animal Physiology
Axonal transport
Biochemistry
Biomedical and Life Sciences
Danio rerio
Dementia disorders
Evolutionary Biology
Life Sciences
Microtubules
Molecular modelling
Neurodegenerative diseases
Reviews
Tau protein
taupathies
neurodegeneration
zebrafish
animal model
tau protein
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Summary:Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of the tau protein in the brain, which causes clinical dementia. The tau protein stabilizes microtubules and regulates axonal transport, however, when hyper-phosphorylated, it aggregates in the brain. Tauopaties can be divided into primary and secondary (e.g., Alzheimer’s disease). Experimental animal models are an important tool to study tauopathies. Here, we discuss molecular mechanisms of tauopathies and their available experimental models in both rodents and a relatively novel model organism, the zebrafish ( Danio rerio ), as well as outline novel research trends in this field.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093023060133