Correlation between anti-thrombin III level in plasma and cerebro-vascular occlusive diseases

• Published in: Blood & Vessel Vol. 9; no. 1; pp. 126 - 131
• Main Authors: MARUYAMA, Ikuro, FUKUDA, Ruriko, MATSUDA, Juzo, KAZAMA, Mutsuyoshi, ABE, Takeshi, YOSHIDA, Yoshihiro, HAMADA, Rikuzo, IGATA, Akihiro
• Format: Journal Article
• Language: English
• Published: The Japanese Society on Thrombosis and Hemostasis 1978
• Subjects: antithrombin III; cerebral thrombosis; hypercoagulability; oral contraceptives
• ISSN: 0386-9717; 1884-2372
• DOI: 10.2491/jjsth1970.9.126

The inhibitors of coagulation and fibrinolysis are expected to play the important role in the thrombosis and hemostasis as one of the regulatory factor. Activity and antigenicity of antithrombin III (AT-III), the most predominant coagulation inhibitor in blood, were assayed in various cerebro-vascular occlusive diseases (53 cases of cerebral thrombosis, 4 cases of transient ischemic attack or reversible ischemic neurological deficit, one case of homocystinuria and 3 cases of Werner' syndrome). And the correlation was realized between the clinical symptomes and levels of this factor in cases of normal control, cerebral hemorrhage and disseminated intravascular coagulation syndrome. 1) Normal level of plasma AT-III was from 30mg/dl to 34mg/dl. 2) Among 51 cases of cerebral thrombosis, 38 cases (75%) showed low AT-III (below than 30mg/dl) than normal control. It was also low level in 4 cases of transient ischemic attack or reversible ischemic neurological deficit. 3) A 32-year-old woman who had been taking “Lyndiol” (compound of estrogen and progesteron) for 22 days and attacked by cerebral thrombosis probably due to low AT-III induced by this oral contraceptives. 4) A 12-year-old girl of homocystinuria had the episodes of recurrent cerebral thrombotic attacks. Laboratory examinations revealed the increased serum methionine and homocystine, together with the low AT-III (67%) and abnormal vascular changes. Her parents were thought to be heterozygotes because of normal levels of serum methionine and homocystine. Although the levels of AT-III in the parents were also decreased (67% and 71%), they had not any episode of thrombosis. 5) Low plasma AT-III was thought one of the risk factor of cerebro-vascular occulusive diseases. The risk of attack would be more higher, if it was accompanied with vascular abnormality.