Human c-fms Proto-Oncogene: Comparative Analysis with an Abnormal Allele

The organization of the human c-fms proto-oncogene has been determined and compared with an abnormal allele. The human v-fms homologous genetic sequences are dispersed discontinuously and colinearly with the viral oncogene over a DNA region of ca. 32 kilobase pairs. The abnormal c-fms locus contains...

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Published inMolecular and cellular biology Vol. 5; no. 2; pp. 422 - 426
Main Authors Verbeek, Joseph S., Roebroek, Anton J. M., van den Ouweland, Aans M. W., Bloemers, Henri P. J., Van de Ven, Wim J. M.
Format Journal Article
LanguageEnglish
Published Taylor & Francis 01.02.1985
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Summary:The organization of the human c-fms proto-oncogene has been determined and compared with an abnormal allele. The human v-fms homologous genetic sequences are dispersed discontinuously and colinearly with the viral oncogene over a DNA region of ca. 32 kilobase pairs. The abnormal c-fms locus contains a small deletion in its 3′ portion. DNA sequencing analysis indicated that it was 426 base pairs in size and located in close proximity to a putative c-fms exon.
ISSN:1098-5549
1098-5549
DOI:10.1128/mcb.5.2.422-426.1985