An economical hemoperfusion system to determine in vitro clearances of various poisons with different adsorbents

An economical hemoperfusion system for clearance studies in vitro was developped. It was ascertained, that hemoperfusion using columns which contain 13 g of adsorbent and perfused at a blood flow rate of 1.25 ml/min results in the same relative clearances as when using clinical sized columns contain...

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Bibliographic Details
Published inArchives of toxicology Vol. 46; no. 3-4; p. 215
Main Authors Okonek, S, Reininghaus, I, Setyadharma, H, Gaudron, P
Format Journal Article
LanguageEnglish
Published Germany 01.12.1980
Subjects
Adsorption
Animals
Digitoxin - poisoning
Hemoperfusion - methods
Humans
Kinetics
Methaqualone - poisoning
Methyl Parathion - poisoning
Paraquat - poisoning
Parathion - poisoning
Poisoning - therapy
Poisons - blood
Rats
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Summary:An economical hemoperfusion system for clearance studies in vitro was developped. It was ascertained, that hemoperfusion using columns which contain 13 g of adsorbent and perfused at a blood flow rate of 1.25 ml/min results in the same relative clearances as when using clinical sized columns containing 300--355 g of the absorbent and run at 100ml/min. The adsorption kinetics of toxicologically important drugs and pesticides are given as examples. To date 27 substances were tested systematically. The investigation has shown, that no adsorbent is without exception the best one, but the efficacy can vary from substance to substance.
ISSN:0340-5761
DOI:10.1007/BF00310437