Genistein Inhibits the Proliferation of MDA-MB-231 Cells In Vivo

• Published in: Journal of food science and nutrition (Pusan, Korea : 2003) Vol. 12; no. 1
• Main Authors: Kim, Y.K. (Kyungpook National University, Daegu, Republic of Korea), E-mail: yookim@mail.knu.ac.kr, Kim, H.A. (Mokpo National University, Muan, Republic of Korea), Park, M.Y. (Mokpo National University, Muan, Republic of Korea), Do, S.H. (Kyungpook National University, Daegu, Republic of Korea)
• Format: Journal Article
• Language: English
• Published: 01.03.2007
• Subjects: GENISTEIN; GENISTEINA; GENISTEINE; in vivo; MDA-MB-231 cell; soy extract; tumor growth
• ISSN: 1226-332X
• DOI: 10.3746/jfn.2007.12.1.011

This study was conducted to evaluate the influence of diets containing genistein and soy extract on the growth of MDA-MB-231 cells implanted into female Balb/c mice. Four-week-old female athymic nude mice (Balb/c) were acclimated to an AIN-93G control diet for 1 week and then injected MDA-MB-231 cells (1×10∨6/site) and were continued on the on AIN-93G control diet. Five weeks after injecting the MDA-MB-231 cells (1×10∨6/site), two experimental groups were assigned to diets containing genistein (750 ㎍/g AIN-93G diet) or 0.6% soy extract (containing genistein at 750 ㎍/g AIN-93G diet) until they were sacrificed.