TSG-6, a glycoprotein associated with arthritis, and its ligand hyaluronan exert opposite effects in a murine model of inflammation

• Published in: Pflügers Archiv Vol. 431; no. 6 Suppl 2; p. R225
• Main Authors: Wisniewski, H G, Naime, D, Hua, J C, Vilcek, J, Cronstein, B N
• Format: Journal Article
• Language: English
• Published: Germany 1996
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Arthritis - metabolism; Carrageenan; Cell Adhesion Molecules - metabolism; Cell Adhesion Molecules - pharmacology; Female; Humans; Hyaluronic Acid - pharmacology; Inflammation - chemically induced; Inflammation - drug therapy; Inflammation - pathology; Mice; Mice, Inbred BALB C; Recombinant Proteins - pharmacology
• ISSN: 0031-6768; 1432-2013
• DOI: 10.1007/bf02346350

TSG-6 is an arthritis-associated hyaluronan binding protein whose production in synovial cells, chondrocytes, fibroblasts and mononuclear cells is stimulated by TNF-alpha and IL-1. The purpose of this study was to gain insights into the role of TSG-6 and its functional interactions with hyaluronan in inflammation. In the murine air pouch model of carrageenan/IL-1-induced inflammation TSG-6 showed a dramatic inhibitory effect on the cellular infiltration of the inflammatory site by neutrophilic PMN, while hyaluronan enhanced cellular infiltration. There was no indication of a neutralizing or cooperative effect when TSG-6 and hyaluronan were injected together. The potent antiinflammatory effect of TSG-6 along with its induction by proinflammatory cytokines suggests that TSG-6 is part of a negative feedback loop in the control of the inflammatory response.