Asymmetric synthesis of 2,4,5-substituted prolines through 1,3-dipolar addition reaction of N-arylidene menthyl esters of alpha-aminoacid with methyl acrylate
Proline and its derivatives constitute the important organic entities as organocatalyst, ACE inhibitors, bioactive molecules/intermediates to bioactive molecules as well as components of various natural products e.g. Kainic acid, (-)-domoic acid, etc. Due to its wide range of utility extensive studi...
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Published in | Indian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 59; no. 7; pp. 1039 - 1042 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
NEW DELHI
Natl Inst Science Communication & Information Resources-Niscair
01.07.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Proline and its derivatives constitute the important organic entities as organocatalyst, ACE inhibitors, bioactive molecules/intermediates to bioactive molecules as well as components of various natural products e.g. Kainic acid, (-)-domoic acid, etc. Due to its wide range of utility extensive studies have been made for the synthesis of 2, 3, 4 or 5 substituted prolines. One pot synthesis of 2,4,5-substituted prolines through 1,3-dipolar addition of various amino acids with homochiral acrylate has also been carried out successfully. Herein we wish to report the 1,3-dipolar addition of Schiff bases, where chiral auxiliary has been introduced in the Schiff bases and 1,3dipolar addition with methyl acrylate leading to the synthesis of 2(S),4(S),5(R)-substituted prolines has been achieved successfully. |
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ISSN: | 0376-4699 0019-5103 0975-0983 |
DOI: | 10.56042/ijcb.v59i7.42578 |