Elimination kinetics of iopamidol, a new water soluble nonionic radiographic contrast medium, analyzed by radioactivation

We have studied the elimination kinetics of iopamidol employing radioactivation and radiochemical separation. This method offers the advantage of guaranteeing absolutely no interference by radiation with tissue distribution or elimination kinetics of the analyzed compound. Our results show that iopa...

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Published inExperientia Vol. 39; no. 1; p. 119
Main Authors Muratore, O, Saitta, S, Mallarini, G, Corvisiero, P, Sanzone, M
Format Journal Article
LanguageEnglish
Published Switzerland 15.01.1983
Subjects
Animals
Brain - metabolism
Contrast Media
Iodine - blood
Iodine - metabolism
Iopamidol
Iothalamic Acid - analogs & derivatives
Iothalamic Acid - metabolism
Kidney - metabolism
Kinetics
Liver - metabolism
Radiochemistry
Rats
Rats, Inbred Strains
Solubility
Thyroid Gland - metabolism
Water
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Abstract We have studied the elimination kinetics of iopamidol employing radioactivation and radiochemical separation. This method offers the advantage of guaranteeing absolutely no interference by radiation with tissue distribution or elimination kinetics of the analyzed compound. Our results show that iopamidol does not cross the blood-brain barrier, has no effect on thyroid iodine uptake and does not accumulate in the liver.
AbstractList We have studied the elimination kinetics of iopamidol employing radioactivation and radiochemical separation. This method offers the advantage of guaranteeing absolutely no interference by radiation with tissue distribution or elimination kinetics of the analyzed compound. Our results show that iopamidol does not cross the blood-brain barrier, has no effect on thyroid iodine uptake and does not accumulate in the liver.
Author Mallarini, G
Sanzone, M
Saitta, S
Muratore, O
Corvisiero, P
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crossref_primary_10_1177_0284185195036S39908
crossref_primary_10_1002_jlcr_2580360305
crossref_primary_10_1007_BF00588184
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Snippet We have studied the elimination kinetics of iopamidol employing radioactivation and radiochemical separation. This method offers the advantage of guaranteeing...
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StartPage 119
SubjectTerms Animals
Brain - metabolism
Contrast Media
Iodine - blood
Iodine - metabolism
Iopamidol
Iothalamic Acid - analogs & derivatives
Iothalamic Acid - metabolism
Kidney - metabolism
Kinetics
Liver - metabolism
Radiochemistry
Rats
Rats, Inbred Strains
Solubility
Thyroid Gland - metabolism
Water
Title Elimination kinetics of iopamidol, a new water soluble nonionic radiographic contrast medium, analyzed by radioactivation
URI https://www.ncbi.nlm.nih.gov/pubmed/6825773
Volume 39
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