Elimination kinetics of iopamidol, a new water soluble nonionic radiographic contrast medium, analyzed by radioactivation

We have studied the elimination kinetics of iopamidol employing radioactivation and radiochemical separation. This method offers the advantage of guaranteeing absolutely no interference by radiation with tissue distribution or elimination kinetics of the analyzed compound. Our results show that iopa...

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Bibliographic Details
Published inExperientia Vol. 39; no. 1; p. 119
Main Authors Muratore, O, Saitta, S, Mallarini, G, Corvisiero, P, Sanzone, M
Format Journal Article
LanguageEnglish
Published Switzerland 15.01.1983
Subjects
Animals
Brain - metabolism
Contrast Media
Iodine - blood
Iodine - metabolism
Iopamidol
Iothalamic Acid - analogs & derivatives
Iothalamic Acid - metabolism
Kidney - metabolism
Kinetics
Liver - metabolism
Radiochemistry
Rats
Rats, Inbred Strains
Solubility
Thyroid Gland - metabolism
Water
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Summary:We have studied the elimination kinetics of iopamidol employing radioactivation and radiochemical separation. This method offers the advantage of guaranteeing absolutely no interference by radiation with tissue distribution or elimination kinetics of the analyzed compound. Our results show that iopamidol does not cross the blood-brain barrier, has no effect on thyroid iodine uptake and does not accumulate in the liver.
ISSN:0014-4754
DOI:10.1007/BF01960664