The agouti coat-color locus may influence brain catecholamines: Regional differences in norepinephrine and dopamine in the brains of two color-morphs of deermice ( Peromyscus maniculatus)

Levels of norepinephrine (NE) and dopamine (DA) were measured by HPLC from the cortex, striatum and brain stem of agouti and nonagouti deermice ( Peromyscus maniculatus gracilis). In the brain stem, agouti animals exhibited significantly higher NE whereas nonagouti animals had significantly higher D...

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Bibliographic Details
Published inComparative biochemistry and physiology. C, Comparative pharmacology and toxicology Vol. 107; no. 1; pp. 51 - 55
Main Authors Hayssen, V., Gunawardhana, S., Meyer, J.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 1994
Subjects
Agouti
Coat-color
Dopamine
Norepinephrine
Peromyscus
Pleiotropy
Pleiotropy
Norepinephrine
Dopamine
Agouti
Peromyscus
Coat-color
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Summary:Levels of norepinephrine (NE) and dopamine (DA) were measured by HPLC from the cortex, striatum and brain stem of agouti and nonagouti deermice ( Peromyscus maniculatus gracilis). In the brain stem, agouti animals exhibited significantly higher NE whereas nonagouti animals had significantly higher DA. In contrast, agouti deermice had nearly twice the DA levels of nonagouti animals in both the cortex and striatum. Levels of cortical and striatal NE were similar in both color morphs, although NE in nonagouti animals was 8% higher and less variable. The variability of both NE and DA was much lower in the brain stem than in either the striatum or the cortex. This is the first evidence of a pleiotropic effect of the agouti coat-color locus on brain catecholamines.
ISSN:0742-8413
DOI:10.1016/1367-8280(94)90009-4