Comparative study of mucoadhesive vaginal tablets of Schinopsis brasiliensis Engler extract formulated with different polymers with antifungal activity

Candida albicans is the main fungus responsible for acute and recurrent vaginal infections. Low adherence to treatment is due to dosing frequency and available topical medications. Thus, we developed mucoadhesive tablets based on Schinopsis brasiliensis Engler extract composed of Carboxymethylcellul...

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Bibliographic Details
Published inBrazilian Journal of Pharmaceutical Sciences Vol. 60
Main Authors Dantas, Mariana Morais, Oshiro-Junior, João Augusto, Fonsêca, Naara Felipe da, Alves-Júnior, José de Oliveira, Bezerra, Brenda Maria Silva, Mendonça y Araújo, Sara Efigênia Dantas de, Medeiros, Ana Cláudia Dantas de
Format Journal Article
LanguageEnglish
Published Sao Paulo Universidade de Sao Paulo Faculdade de Ciencias 01.01.2024
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Subjects
Antibiotics
Cellulose
Drug dosages
Drug resistance
Ethnomedicine
Herbal medicine
Infections
Microbiota
Microorganisms
Molecular weight
Pharmaceuticals
PHARMACOLOGY & PHARMACY
Phytochemicals
Polymers
Vagina
Hydroxypropylmethylcellulose
Pluronic
Vaginal fungal infections
Mucoadhesion
Carboxymethylcellulose
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Summary:Candida albicans is the main fungus responsible for acute and recurrent vaginal infections. Low adherence to treatment is due to dosing frequency and available topical medications. Thus, we developed mucoadhesive tablets based on Schinopsis brasiliensis Engler extract composed of Carboxymethylcellulose (F1), Hydroxypropylmethylcellulose (F2), or Pluronic (F3), against C. albicans . The extract metabolites determination showed presence of polyphenols (15 μg.mg-1), flavonoids (5.51 μg.mg-1), and tannins (4.80 μg.mg-1). The in vitro antifungal activity was performed by broth microdilution method. Quality control tests were performed according international pharmacopeias. Regarding the mucoadhesion test, in terms of the force expressed between the tablet:mucin disc, the average values were approximately 0.1267 N (F1), 0.0411 N (F2) and 0.814 N (F3), while in the tablet:vaginal mucosa, the average values were approximately 0.0294 N (F1), 0.0166 N (F2) and 0.0365 N (F3). The dry extract showed a minimum inhibitory concentration of 62.5 μg.mL-1. In evaluating the in vitro release of tablets, polymers derived from cellulose released 100% in less than 4 hours, while Pluronic released around 56.3% in 72 hours. It is concluded that F1 has greater mucoadhesion while F3 has a modified release rate, providing promising results for future application of the formulation in the clinical assay.Keywords:Vaginal fungal infections; Mucoadhesion; Carboxymethylcellulose; Hydroxypropylmethylcellulose; Pluronic
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902024e23604