Diabetes mellitus as presenting feature in extra-adrenal pheochromocytoma: report of a case

Secondary diabetes mellitus was the main abnormal finding in a young lean woman with benign extra-adrenal para-aortic norepinephrine and dopamine secreting pheochromocytoma. Glucose and insulin response to oral glucose and C-peptide secretion after glucagon i.v. were evaluated before and after alpha...

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Published inActa diabetologica latina Vol. 27; no. 3; p. 261
Main Authors Balestrieri, P G, Spandrio, S, Romanelli, G, Giustina, G
Format Journal Article
LanguageEnglish
Published Italy 01.07.1990
Subjects
Adult
C-Peptide - blood
Diabetes Mellitus - etiology
Female
Glucose Tolerance Test
Humans
Paraganglioma - complications
Pheochromocytoma - complications
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Summary:Secondary diabetes mellitus was the main abnormal finding in a young lean woman with benign extra-adrenal para-aortic norepinephrine and dopamine secreting pheochromocytoma. Glucose and insulin response to oral glucose and C-peptide secretion after glucagon i.v. were evaluated before and after alpha-blockade with phenoxybenzamine. Alpha-blocking treatment restored the inhibited basal and stimulated C-secretion but did not normalize glucose tolerance. After tumor removal metabolic abnormalities were normalized, confirming the role of endogenous catecholamine excess in the pathogenesis of our patient's glucose intolerance.
ISSN:0001-5563
DOI:10.1007/BF02581338