Comparison of technetium 99m Q12 and thallium 201 for detection of angiographically documented coronary artery disease in humans

• Published in: Journal of nuclear cardiology Vol. 1; no. 6; p. 499
• Main Authors: Gerson, M C, Lukes, J, Deutsch, E, Biniakiewicz, D, Rohe, R C, Washburn, L C, Fortman, C, Walsh, R A
• Format: Journal Article
• Language: English
• Published: United States 01.11.1994
• Subjects: Adult; Aged; Coronary Angiography; Coronary Disease - diagnostic imaging; Electrocardiography; Female; Furans; Humans; Male; Middle Aged; Organotechnetium Compounds; Radiation Dosage; Radionuclide Imaging; Thallium Radioisotopes
• ISSN: 1071-3581
• DOI: 10.1007/BF02939972

99mTc-labeled Q12 (99mTc-Q12) is a new imaging agent that produces myocardial visualization in humans. This study examined the hypothesis that a 100-minute rest-exercise tomographic imaging protocol after injection of 99mTc-Q12 can be used to detect the presence or absence of coronary artery stenoses. Imaging with 201Tl and 99mTc-Q12 was performed in 20 patients with angiographically documented coronary artery disease and 10 "normal" subjects including two patients with chest pain and normal coronary arteriograms and eight subjects with a very low likelihood of occlusive coronary disease. 99mTc-Q12 was imaged beginning 15 minutes after injection at rest and with exercise. In the 20 patients, a corresponding myocardial defect was detected in blinded fashion in 18 with 201Tl and 17 with 99mTc-Q12 (difference not significant). Of 10 patients without evidence of coronary disease, nine had a normal 201Tl scan and eight had a normal 99mTc-Q12 scan (difference not significant). Agreement of 99mTc-Q12 and 201Tl imaging for detection of regional myocardial perfusion defects was excellent (kappa = 0.88). Identification of the presence or absence of angiographically documented coronary disease in individual coronary artery distributions was 80% and 82% for 201Tl imaging and 73% and 87% for 99mTc-Q12 (difference not significant). 99mTc-Q12, used in a rest-exercise sequence that can be completed in 100 minutes, provided identification of regional myocardial perfusion defects similar to that of 201Tl.