Pharmacological profile of mifentidine: a novel H2-receptor antagonist
Mifentidine, a representative compound of a novel class of H2-antagonists, has been investigated for its ability to interact with H2-receptors and to inhibit gastric acid secretion. Affinity estimates (KB) of mifentidine obtained from in vitro studies on cardiac and gastric mucosal histamine (H2) re...
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Published in | Agents and actions Vol. 16; no. 3-4; p. 173 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
01.04.1985
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Subjects | |
Online Access | Get more information |
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Summary: | Mifentidine, a representative compound of a novel class of H2-antagonists, has been investigated for its ability to interact with H2-receptors and to inhibit gastric acid secretion. Affinity estimates (KB) of mifentidine obtained from in vitro studies on cardiac and gastric mucosal histamine (H2) receptors were in the 20-50 nM range. Mifentidine appeared to be endowed with strong anti-secretory properties against histamine-stimulated secretion in the anaesthetized rat and in the conscious dog. Distinct features of mifentidine were considerable bioavailability and duration of anti-secretory effect. |
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ISSN: | 0065-4299 |
DOI: | 10.1007/BF01983131 |