Analysis of haplotype preference in the cytotoxic T-cell response to H-Y

The mechanisms determining which parental haplotype is selected in (CBA X B10) (k X b)F1 female mice for major histocompatibility complex (H-2) restricted, male-specific (H-Y), immune, cytotoxic T-cell (Tc-cell) responses, was investigated. The data show that haplotype preference is variable, and ma...

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Bibliographic Details
Published inImmunogenetics (New York) Vol. 13; no. 1-2; p. 133
Main Authors Brenan, M, Simpson, E, Müllbacher, A
Format Journal Article
LanguageEnglish
Published United States 1981
Subjects
Animals
Chimera
Cross Reactions
Cytotoxicity, Immunologic
Feedback
Female
Gene Frequency
Genes
H-2 Antigens - genetics
H-Y Antigen - genetics
Haploidy
Immunization
Male
Mice
Mice, Inbred CBA
T-Lymphocytes - immunology
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Summary:The mechanisms determining which parental haplotype is selected in (CBA X B10) (k X b)F1 female mice for major histocompatibility complex (H-2) restricted, male-specific (H-Y), immune, cytotoxic T-cell (Tc-cell) responses, was investigated. The data show that haplotype preference is variable, and may be directed towards one, both, or neither of the parental haplotypes. This preference is reflected in the precursor or frequency of memory Tc cells as measured by limiting dilution assays. It was further shown that maternal influence, antigen dose, route of immunization, and a feedback mechanism on the stimulator cells in vivo could not influence haplotype preference or its observed variability. Evidence for cross-reactive killing by H-2k and H-2b H-Y immune Tc cells on H-2b and H-2k allogeneic targets, respectively,, (i.e., the independent haplotype of the other parent of the F1 mice), provide evidence for natural tolerance as a possible mechanism to explain haplotype preference.
ISSN:0093-7711
DOI:10.1007/BF00524611