Synthesis and biological evaluation of novel phosphonyl thiazolo pyrazoles
A series of novel dimethyl 7-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-4-(4-fluorophenyl)-9-oxo-8-phenyl-6-thia-1,2,8-triazaspiro[4.4]non-2-en-3-ylphosphonate 11a-g have been synthesized by the reaction of chalcone derivatives of (E)-5-benzylidene-2-((...
Saved in:
Published in | Indian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 59; no. 6; pp. 867 - 876 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
NEW DELHI
Natl Inst Science Communication & Information Resources-Niscair
01.06.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | A series of novel dimethyl 7-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-4-(4-fluorophenyl)-9-oxo-8-phenyl-6-thia-1,2,8-triazaspiro[4.4]non-2-en-3-ylphosphonate 11a-g have been synthesized by the reaction of chalcone derivatives of (E)-5-benzylidene-2-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-phenylthiazolidin-4-one 10a-g with Bestmen Ohira reagent. The chemical structures of newly synthesized compounds have been elucidated by IR, NMR, MS and elemental analysis. The compounds 11a-g have been evaluated for their nematicidal activity against Dietylenchus myceliophagus and Caenorhabditis elegans. Compound 11b, 11c, 11g and 11f show appreciable nematicidal activity. |
---|---|
ISSN: | 0376-4699 0019-5103 0975-0983 |
DOI: | 10.56042/ijcb.v59i6.42526 |