Synthesis and biological evaluation of novel phosphonyl thiazolo pyrazoles

A series of novel dimethyl 7-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-4-(4-fluorophenyl)-9-oxo-8-phenyl-6-thia-1,2,8-triazaspiro[4.4]non-2-en-3-ylphosphonate 11a-g have been synthesized by the reaction of chalcone derivatives of (E)-5-benzylidene-2-((...

Full description

Saved in:
Bibliographic Details
Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 59; no. 6; pp. 867 - 876
Main Authors Srinivas, Avula, Sunitha, Malladi, Karthik, Pulluri, Reddy, K. Vasumathi
Format Journal Article
LanguageEnglish
Published NEW DELHI Natl Inst Science Communication & Information Resources-Niscair 01.06.2020
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
click reaction
CLICK CHEMISTRY
NUCLEOSIDES
Phosponylpyrazoles
EXPEDIENT SYNTHESIS
SITU
IN-VITRO
ACETYLCHOLINESTERASE
TRIAZOLE
cyclisation
Knovenagel condensation
Bestmenohira reagent
INHIBITOR
CP-060S
nematicidal activity
PROTEASE
Online AccessGet full text

Cover

More Information
Summary:A series of novel dimethyl 7-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-4-(4-fluorophenyl)-9-oxo-8-phenyl-6-thia-1,2,8-triazaspiro[4.4]non-2-en-3-ylphosphonate 11a-g have been synthesized by the reaction of chalcone derivatives of (E)-5-benzylidene-2-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-phenylthiazolidin-4-one 10a-g with Bestmen Ohira reagent. The chemical structures of newly synthesized compounds have been elucidated by IR, NMR, MS and elemental analysis. The compounds 11a-g have been evaluated for their nematicidal activity against Dietylenchus myceliophagus and Caenorhabditis elegans. Compound 11b, 11c, 11g and 11f show appreciable nematicidal activity.
ISSN:0376-4699
0019-5103
0975-0983
DOI:10.56042/ijcb.v59i6.42526