A solid-state electrochemiluminescence composite modified electrode based on Ru(bpy)32+/PAHNSA: Characterization and pharmaceutical applications

• Published in: Electrochimica acta Vol. 176; pp. 179 - 187
• Main Authors: Al-Hinaai, Mohammed, Khudaish, Emad A., Al-Harthy, Salim, Suliman, FakhrEldin O.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 10.09.2015
• Subjects: Chlorpheniramine maleate; Electrochemiluninescence; Poly(4-amino-3-hydroxynaphthalene sulfonic acid); Sensors; Tris(bipyridyl)ruthenium(II); Electrochemiluninescence; Poly(4-amino-3-hydroxynaphthalene sulfonic acid); Sensors; Tris(bipyridyl)ruthenium(II); Chlorpheniramine maleate
• ISSN: 0013-4686; 1873-3859
• DOI: 10.1016/j.electacta.2015.06.148

A composite electrochemiluminescence (ECL) sensor was constructed by electrochemical polymerization of 4-amino-3-hydroxynaphthalene sulfonic acid (AHNSA) and tris(2,2′-bipyridyl) ruthenium(II), [Ru(bpy)3]2+, from their aqueous solutions at glassy carbon electrode (GCE). The proposed one-step electrochemical synthesis of the composite film (Ru/PAHNSA/GCE) provides a stable and reactive luminescent for the quantification of chlorpheniramine maleate (CPM) in its pharmaceutical preparations. The properties and the structure of the modified surface were studied using typical voltammetric, Electrochemical Impedance Spectroscopy (EIS), X-Ray Photoelectron Spectroscopy (XPS) and Atomic Force Microscopy (AFM) methods. The intensity of the ECL as a function of [CPM] is linear for the range between 0.2 and 32μgmL−1 with a detection limit of 0.023μgmL−1. The performance of the sensor was tested in the presence of interference species and for real sample analysis under optimal conditions.