Development of Cellular Therapeutics for Cancer Treatment: Functional Enhancements Without Genetic Modification

The treatment landscape for malignant tumors, particularly solid tumors, has undergone profound shifts with the emergence and development of molecularly targeted therapies and advanced immunotherapeutic agents. These innovative approaches have contributed to steadily improving therapeutic outcomes,...

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Bibliographic Details
Published inDrug Delivery System Vol. 40; no. 2; pp. 108 - 116
Main Author Harada, Yui
Format Journal Article
LanguageJapanese
Published THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM 25.03.2025
Subjects
Engager
immunotherapy
Malignant tumor
NK cell
off-the-shelf
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ISSN0913-5006
1881-2732
DOI10.2745/dds.40.108

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Summary:The treatment landscape for malignant tumors, particularly solid tumors, has undergone profound shifts with the emergence and development of molecularly targeted therapies and advanced immunotherapeutic agents. These innovative approaches have contributed to steadily improving therapeutic outcomes, and in many cases, early detection paired with prompt intervention has enabled curative treatment. However, malignant tumors remain the leading cause of mortality in Japan - a reflection of the limited success in treating certain cancer types despite advances in technology and therapeutics. At the forefront of therapeutic technology development, significant efforts are being devoted to enhancing the functionality of cell-based therapeutics. This article focuses particularly on surface modifications applied to cells without genetic modifications. We hope it will contribute to a deeper understanding of the mechanisms of action and therapeutic strategies of newly emerging agents, while also strengthening the momentum toward the eradication of cancer.
ISSN:0913-5006
1881-2732
DOI:10.2745/dds.40.108