Cardiac Regeneration Therapy Using Cell Sheet Technology
Cardiac diseases are on the increase worldwide, and new treatment approaches that complement existing therapies, such as assisted ventricular assist devices and heart transplants, are being developed. Cell transplantation therapy has gained significant focus as a treatment aimed at regenerating myoc...
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| Published in | Drug Delivery System Vol. 40; no. 2; pp. 127 - 131 |
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| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM
25.03.2025
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0913-5006 1881-2732 |
| DOI | 10.2745/dds.40.127 |
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| Abstract | Cardiac diseases are on the increase worldwide, and new treatment approaches that complement existing therapies, such as assisted ventricular assist devices and heart transplants, are being developed. Cell transplantation therapy has gained significant focus as a treatment aimed at regenerating myocardium, and methods using cell sheet technology have progressed from basic research to clinical application. The Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine has been pursuing the clinical application of cell transplantation therapy for heart failure patients, starting with autologous skeletal myoblast cell sheets, followed by iPS cell-derived cardiomyocyte sheets, and then adipose stem cell spray transplantation, which was developed based on cell sheet technology. This report outlines the background and status of the development of myocardial regeneration therapy by cell transplantation in our department. |
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| AbstractList | Cardiac diseases are on the increase worldwide, and new treatment approaches that complement existing therapies, such as assisted ventricular assist devices and heart transplants, are being developed. Cell transplantation therapy has gained significant focus as a treatment aimed at regenerating myocardium, and methods using cell sheet technology have progressed from basic research to clinical application. The Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine has been pursuing the clinical application of cell transplantation therapy for heart failure patients, starting with autologous skeletal myoblast cell sheets, followed by iPS cell-derived cardiomyocyte sheets, and then adipose stem cell spray transplantation, which was developed based on cell sheet technology. This report outlines the background and status of the development of myocardial regeneration therapy by cell transplantation in our department. |
| Author | Kawamura, Takuji |
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| Copyright | 2025 The Japan Society of Drug Delivery System |
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| DOI | 10.2745/dds.40.127 |
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| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1881-2732 |
| EndPage | 131 |
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| References | 3）Menasché, P., et al., J. Am. Coll. Cardiol., 71, 429-438 （2018 19）Kawamura, T., et al., Stem cells Tansl. Mdicine, 4, 1258-1264 （2015 7）Memon, I.A., et al., J. Thorac. Cardiovasc. Surg., 130, 1333-1341 （2005 21）Kashiyama, N., et al., Transplantation, 103, 1582-1590 （2019 2）Patel, A.N., et al., Lancet, 387, 2412-2421 （2016 4）Okano, T., et al., J. Biomed. Mater. Res., 27, 1243-1251 （1993 22）Kawamura, T., et al., Front. Cardiovasc. Med., 10, 1182203 （2023 1）Menasché, P., et al., Circulation, 117, 1189-1200 （2008 27）Kawamura, T., et al., J. Transl. Med., 22, 1091 （2024 8）Kondoh, H., et al., J. Thorac. Cardiovasc. Surg., 130, 295-302 （2005 26）Mori, D., et al., Transplantation, 102, 2012-2024 （2018 16）Ishida, M., et al., Transplantation, 103, 291-298 （2019 14）Yu, T., et al., Circ. J., 77, 1297-1306 （2013 20）Kawamura, T., et al., Stem Cell Reports, 6, 312-320 （2016 12）Kainuma, S., et al., Mol. Ther., 29, 1425-1438 （2021 15）Kawamura, M., Circulation, 126, S29-37 （2012 10）Yoshikawa, Y., et al., Surgery today, 48, 200-210 （2018 23）Miyagawa, S., et al., Front. Cardiovasc. Med.,9, 950829 （2022 11）Miyagawa, S., et al., J. Am. Heart Assoc., 6, e003918 （2017 24）Kanelidis, A.J., et al., Circ. Res., 120, 1139-1150 （2017 5）Shimizu, T., et al., Tissue Eng., 7, 141-151 （2001 18）Kawamura, T., et al., PloS one , 9, e111064 （2014 6）Miyagawa, S., et al., Transplantation, 80, 1586-1595 （2005 13）Sawa, Y., et al., Circ. J., 79, 991-999 （2015 9）Hata, H., et al., J. Thorac. Cardiovasc. Surg., 132, 918-924 （2006 25）Bobi, J., et al., J. Am. Heart Assoc., 6, e005771 （2017 17）Higuchi, T., et al., Cell transplantation, （2015）. https://doi.org：10.3727/096368914x685799 |
| References_xml | – reference: 22）Kawamura, T., et al., Front. Cardiovasc. Med., 10, 1182203 （2023） – reference: 17）Higuchi, T., et al., Cell transplantation, （2015）. https://doi.org：10.3727/096368914x685799 – reference: 2）Patel, A.N., et al., Lancet, 387, 2412-2421 （2016） – reference: 9）Hata, H., et al., J. Thorac. Cardiovasc. Surg., 132, 918-924 （2006） – reference: 18）Kawamura, T., et al., PloS one , 9, e111064 （2014） – reference: 15）Kawamura, M., Circulation, 126, S29-37 （2012） – reference: 1）Menasché, P., et al., Circulation, 117, 1189-1200 （2008） – reference: 12）Kainuma, S., et al., Mol. Ther., 29, 1425-1438 （2021） – reference: 4）Okano, T., et al., J. Biomed. Mater. Res., 27, 1243-1251 （1993） – reference: 25）Bobi, J., et al., J. Am. Heart Assoc., 6, e005771 （2017） – reference: 21）Kashiyama, N., et al., Transplantation, 103, 1582-1590 （2019） – reference: 13）Sawa, Y., et al., Circ. J., 79, 991-999 （2015） – reference: 23）Miyagawa, S., et al., Front. Cardiovasc. Med.,9, 950829 （2022） – reference: 7）Memon, I.A., et al., J. Thorac. Cardiovasc. Surg., 130, 1333-1341 （2005） – reference: 19）Kawamura, T., et al., Stem cells Tansl. Mdicine, 4, 1258-1264 （2015） – reference: 14）Yu, T., et al., Circ. J., 77, 1297-1306 （2013） – reference: 8）Kondoh, H., et al., J. Thorac. Cardiovasc. Surg., 130, 295-302 （2005） – reference: 3）Menasché, P., et al., J. Am. Coll. Cardiol., 71, 429-438 （2018） – reference: 10）Yoshikawa, Y., et al., Surgery today, 48, 200-210 （2018） – reference: 6）Miyagawa, S., et al., Transplantation, 80, 1586-1595 （2005） – reference: 16）Ishida, M., et al., Transplantation, 103, 291-298 （2019） – reference: 24）Kanelidis, A.J., et al., Circ. Res., 120, 1139-1150 （2017） – reference: 20）Kawamura, T., et al., Stem Cell Reports, 6, 312-320 （2016） – reference: 5）Shimizu, T., et al., Tissue Eng., 7, 141-151 （2001） – reference: 11）Miyagawa, S., et al., J. Am. Heart Assoc., 6, e003918 （2017） – reference: 26）Mori, D., et al., Transplantation, 102, 2012-2024 （2018） – reference: 27）Kawamura, T., et al., J. Transl. Med., 22, 1091 （2024） |
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| Snippet | Cardiac diseases are on the increase worldwide, and new treatment approaches that complement existing therapies, such as assisted ventricular assist devices... |
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| SubjectTerms | cell sheet technology cell therapy Heat failure stem cell |
| Title | Cardiac Regeneration Therapy Using Cell Sheet Technology |
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