Cardiac Regeneration Therapy Using Cell Sheet Technology

Cardiac diseases are on the increase worldwide, and new treatment approaches that complement existing therapies, such as assisted ventricular assist devices and heart transplants, are being developed. Cell transplantation therapy has gained significant focus as a treatment aimed at regenerating myoc...

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Bibliographic Details
Published inDrug Delivery System Vol. 40; no. 2; pp. 127 - 131
Main Author Kawamura, Takuji
Format Journal Article
LanguageJapanese
Published THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM 25.03.2025
Subjects
cell sheet technology
cell therapy
Heat failure
stem cell
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ISSN0913-5006
1881-2732
DOI10.2745/dds.40.127

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Summary:Cardiac diseases are on the increase worldwide, and new treatment approaches that complement existing therapies, such as assisted ventricular assist devices and heart transplants, are being developed. Cell transplantation therapy has gained significant focus as a treatment aimed at regenerating myocardium, and methods using cell sheet technology have progressed from basic research to clinical application. The Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine has been pursuing the clinical application of cell transplantation therapy for heart failure patients, starting with autologous skeletal myoblast cell sheets, followed by iPS cell-derived cardiomyocyte sheets, and then adipose stem cell spray transplantation, which was developed based on cell sheet technology. This report outlines the background and status of the development of myocardial regeneration therapy by cell transplantation in our department.
ISSN:0913-5006
1881-2732
DOI:10.2745/dds.40.127