Intraoperative detection of ganglioneuromas with 123I-MIBG

Radioactive MIBG can be used in radioguided surgery for neuroendocrine tumors. We report the case of a man with a mutation in the succinate dehydrogenase subunit B (SDHB) gene, in which an abdominal MRI scan identified two 5-mm left para-aortic nodules, suspect for paragangliomas. Subsequent SPECT r...

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Bibliographic Details
Published inClinical nuclear medicine Vol. 37; no. 8; p. 768
Main Authors van Hulsteijn, Leonie Theresia, van der Hiel, Bernies, Smit, Jan W A, Stokkel, Marcel P, Corssmit, Eleonora P M
Format Journal Article
LanguageEnglish
Published United States 01.08.2012
Subjects
3-Iodobenzylguanidine
Adult
Ganglioneuroma - diagnostic imaging
Ganglioneuroma - pathology
Ganglioneuroma - surgery
Humans
Intraoperative Care
Magnetic Resonance Imaging
Male
Radionuclide Imaging
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Summary:Radioactive MIBG can be used in radioguided surgery for neuroendocrine tumors. We report the case of a man with a mutation in the succinate dehydrogenase subunit B (SDHB) gene, in which an abdominal MRI scan identified two 5-mm left para-aortic nodules, suspect for paragangliomas. Subsequent SPECT revealed increased uptake of tracer. 123I MIBG probe-guided resection was scheduled. During surgery, 2 small nodules with elevated activity in between the superior mesenteric artery and the left adrenal gland were identified by the detection probe and were resected. Histopathologic examination revealed mature ganglioneuromas.
ISSN:1536-0229
DOI:10.1097/RLU.0b013e31825add9b