O-GlcNAcylation Modification in Immune Cells: Potential Therapeutic Implications of Sepsis

O-GlcNAc modification is a glycosylation modification that is commonly observed in nuclear and organelle proteins of cells. In recent years, several studies have shown that O-GlcNAc modification plays an important regulatory role in immune cells, which regulates their activity and function and inhib...

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Bibliographic Details
Published inIntensive care research Vol. 3; no. 3; pp. 204 - 214
Main Authors Huang, ZhenZhen, Qin, YuanMei
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.09.2023
Springer
Subjects
Immune cells
Inflammation
Medicine
Medicine & Public Health
O-GlcNAcylation modification
Review Article
Sepsis
Sepsis
Inflammation
Immune cells
O-GlcNAcylation modification
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Summary:O-GlcNAc modification is a glycosylation modification that is commonly observed in nuclear and organelle proteins of cells. In recent years, several studies have shown that O-GlcNAc modification plays an important regulatory role in immune cells, which regulates their activity and function and inhibits inflammatory responses. It also enhances immune cells recognition and clearance of pathogens, and improves the host´s antibacterial immune response. Sepsis is a systemic inflammatory response to infection, whose development and progression are regulated by the immune system. Therefore, in the present review, we will discuss the mechanism of O-GlcNAc modification in immune cells and its potential therapeutic value in sepsis, which will be expected to provide new insights and targets for the treatment of sepsis.
ISSN:2666-9862
2666-9862
DOI:10.1007/s44231-023-00048-1