Visual Acuity Outcomes and Complications after Intraocular Lens Exchange

• Published in: Ophthalmology (Rochester, Minn.) Vol. 131; no. 4; pp. 403 - 411
• Main Authors: Son, Hyeck-Soo, Chang, David F., Li, Charles, Liu, Lynn, Zafar, Sidra, Lum, Flora, Woreta, Fasika A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.04.2024
• Subjects: Complications; Intraocular lens exchange; IRIS® Registry; Visual acuity; IRIS; SD; Intraocular lens exchange; BCVA; OR; Complications; IRIS® Registry; CI; IOL; Visual acuity; VA; logMAR
• ISSN: 0161-6420; 1549-4713
• DOI: 10.1016/j.ophtha.2023.10.021

To assess risk factors for worse visual acuity (VA) outcomes after intraocular lens (IOL) exchange, and the most common postsurgical complications. Retrospective cohort study. Eyes from patients 18 years of age and older in the IRIS® Registry (Intelligent Research in Sight) that underwent IOL exchange in the United States between 2013 and 2019. Vision improvement compared with baseline was determined at 1 year after surgery. A multivariable generalized estimating equation model adjusting for demographic factors and baseline vision was used to identify factors associated with VA worse than 20/40 at 1 year. Visual outcomes and postoperative complications after lens exchange. A total of 46 063 procedures (n = 41 925 unique patients) were included in the analysis. Overall, VA improved from a mean ± standard deviation (SD) of 0.53 ± 0.58 logarithm of the minimum angle of resolution (logMAR; Snellen equivalent, 20/70) before surgery to a mean ± SD of 0.31 ± 0.40 logMAR (Snellen equivalent, 20/40) at 1 year. Among eyes with VA recorded at both baseline and 1 year after surgery, 60.5% achieved VA of 20/40 or better at 1 year. Vision of worse than 20/40 at 1 year was associated with greater age (odds ratio [OR], 1.16 per 5-year increase; 95% confidence interval [CI], 1.14–1.18) and higher logMAR baseline VA (OR, 1.14 per 0.1-logMAR increase; 95% CI, 1.14–1.15), as well as Black or African American (OR, 1.96; 95% CI, 1.68–2.28), Hispanic (OR, 1.82; 95% CI, 1.59–2.08), and Asian (OR, 1.48; 95% CI, 1.21–1.81) race or ethnicity versus White race, Medicaid (OR, 1.78; 95% CI, 1.40–2.25) versus private insurance, smoking history (OR, 1.22; 95% CI, 1.11–1.35), and concurrent anterior (OR, 1.65; 95% CI, 1.51–1.81) and posterior (OR, 1.53; 95% CI, 1.41–1.66) vitrectomy versus no vitrectomy. Female sex was associated with better VA at 1 year. At 1 year, epiretinal membrane (10.9%), mechanical lens complication (9.4%), and dislocation of the replacement lens (7.1%) were the most common complications. In this large national cohort, the annual number of IOL exchanges rose steadily over time. Vision improved in 60.2% of patients; worse visual outcomes were associated with greater age, worse baseline vision, Black race, Hispanic ethnicity, Medicaid insurance, smoking, and concurrent vitrectomy. Epiretinal membrane was the most common complication. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.