Changes in liver and spleen volume in alcoholic liver fibrosis of man

• Published in: Kanzo Vol. 28; no. 8; pp. 1051 - 1056
• Main Authors: IKEDA, Toshio, TARAO, Kazuo, MATSUMOTO, Shigehiko, TAMAI, Setsuo, IMORI, Kazuto, OKADA, Kenzo, MIYAMOTO, Shigeo, KAZATO, Kazutami, OIKAWA, Yubo, HAYASHI, Kazuhiro, UCHIKOSHI, Toshiyuki, HOSHINO, Hiroshi, SAKURAI, Akira, UNAYAMA, Shiro
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Hepatology 1987
• Subjects: alcoholic liver fibrosis; CTscan
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.28.1051

Liver and spleen volume were measured by computed tomography in 8 healthy volunteers and in 19 patients with alcoholic liver fibrosis. Patients with alcoholic liver fibrosis were divided into three groups (8 of Grade 1, 5 of Grade 2, and 6 of Grade 3) according to the severity of fibrosis. Each volume was calculated by adding together the area measurements obtained from successive transverse abdominal scans. In the liver volume (mean±SD), alcoholic liver fibrosis Grade 2(1, 284±1533) is significantly larger than the healthy volunteer (1, 027±793, p<0.01)or Grade 1(1, 096±1873, p<0.01), and Grade 3(1, 481±1653)is significantly larger than Grade 1(p<0.01). The mean volume of hepatocytes was significantly larger in Group 3 than in Group 2 or 1. In the spleen volume, Grade 2 (59±63)was significantly(p<0.01) smaller than the healthy volunteer(84±133) or Grade 1 (84±403), and Grade 3(147±363)is significantly(p<0.01)larger than Grade 1. In the alcoholic liver fibrosis, liver volume is increasing as the Grade of fibrosis advances.