Effect of Sugammadex on Coagulation Parameters in Cesarean Section Patients a Prospective Controlled Observational Study

• Published in: European Journal of Therapeutics Vol. 27; no. 4; p. 293
• Main Authors: Destegul, Emre, Destegul, Dilek, Kocaoz, Fazilet
• Format: Journal Article
• Language: English
• Published: AVES 01.12.2021
• Subjects: Cesarean section; Complications; Complications and side effects; Hemostatic techniques; Methods; Patient outcomes; Surgery; Turkey
• ISSN: 2564-7784
• DOI: 10.5152/eurjther.2021.21003

Objective: To evaluate, for the first time in the literature, the effect of sugammadex in elective C/S patients in terms of hemostatic parameters and postoperative bleeding. Methods: Seventy-six patients enrolled for this observational prospective controlled study. Patients were divided into two groups according to anesthetic reversal agent: sugammadex (group I) vs neostigmin (group II). Intraoperative and postoperative amount of bleeding were recorded. At the end of the surgery, after administration of reversal agent, and at postoperative 30th minute, 1st, and 2nd hours, activated partial thromboplastin time (aPTT), prothrombin time (PT), and international normalized ratio (INR) values were recorded. Postoperative Hct, Hgb, and Plt values at 6th and 24th hours of reversal agent administration were also recorded. Results: Alterations in aPTT, PT, and INR values were similar between the groups (P = .986, .549, .05, respectively). Conclusion: Sugammadex at 2 mg [kg.sup.-1] in cesarean section patients has a similar effect on coagulation parameters compared to neostigmin. Further studies are needed particularly in patients under thromboprophylaxis. Keywords: Cesarean section, coagulation, sugammadex, aPTT, neostigmin, postpartum bleeding