Investigation of 2-oxopyrrolidine 5-carboxylic acid amides derivatives as potential anti-tubercular agents based on the similarity screening results from molecular fingerprints and SWISS SIMILARITY

Many open source in silico tools are available for drug discovery. This paper attempts to correlate the results obtained from two such tools with results obtained from in vitro screening. Discovery of novel Anti-TB agents became a necessity due to the ever increasing problem of drug resistance. As h...

Full description

Saved in:
Bibliographic Details
Published inINDIAN JOURNAL OF CHEMISTRY Vol. 62; no. 1; pp. 72 - 75
Main Authors Nagasree, K. P., Umarani, W. A., Sony, K. P. K., Kumar, K. S., Kumar, M. Murali Krishna
Format Journal Article
LanguageEnglish
Published NEW DELHI NATL INST SCIENCE COMMUNICATION & POLICY RESEARCH-NIScPR 01.01.2023
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
anti-tubercular activity
MYCOBACTERIUM-TUBERCULOSIS
ASSAY
Pyroglutamic acid
CHEMDES
2-oxopyrrolidine 5-carboxylic acid amides derivatives
SWISS SIMILARITY
DRUG-RESISTANT TUBERCULOSIS
Online AccessGet full text

Cover

More Information
Summary:Many open source in silico tools are available for drug discovery. This paper attempts to correlate the results obtained from two such tools with results obtained from in vitro screening. Discovery of novel Anti-TB agents became a necessity due to the ever increasing problem of drug resistance. As heterocyclic compounds are known to possess potent biological activity, here an attempt has been made to synthesize pyrazolidine derivatives from pyroglutamic acid. Further the synthesized derivatives are analyzed by IR, NMR and Mass spectral studies and screened for anti-tubercular and antimicrobial activity.
ISSN:0019-5103
2583-1321
DOI:10.56042/ijc.v62i1.70391