A technique for quantitating enzyme histochemistry in adjuvant arthritic joints. II. Acid phosphatase

This paper reports on the incorporation of acid phosphatase histochemistry with a quantitative technique designed to measure the percentage of histochemically-localized enzyme-reactive cells found in adjuvant arthritic articular cartilage, synovial membrane and bone marrow. With the data presented a...

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Bibliographic Details
Published inThe Histochemical journal Vol. 11; no. 5; p. 587
Main Authors Nusbickel, F R, Johnson, W
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.1979
Subjects
Acid Phosphatase - metabolism
Animals
Arthritis - enzymology
Arthritis, Experimental - enzymology
Arthritis, Experimental - pathology
Bone Marrow - enzymology
Cartilage, Articular - enzymology
Histocytochemistry
Histological Techniques
Humans
Male
Methods
Synovial Membrane - enzymology
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Summary:This paper reports on the incorporation of acid phosphatase histochemistry with a quantitative technique designed to measure the percentage of histochemically-localized enzyme-reactive cells found in adjuvant arthritic articular cartilage, synovial membrane and bone marrow. With the data presented and the comparisons made, this incorporation is validated and adjuvant arthritic acid phosphatase "lesions" established. In addition to discussing the importance of the histochemical data and its relationship with intra-articular lysosomes, the applicability of the reactive cell values to drug inhibition studies is discussed.
ISSN:0018-2214
DOI:10.1007/BF01012541