Haemostatic effect of triglycylvasopressin on bleeding from gastric mucosal lesions in the rat

The haemostatic effect of triglycylvasopressin (TGLVP) on the gastric mucosa was evaluated in an experimental model in the rat. TGLVP was found to reduce the bleeding significantly compared with the untreated controls. The haemostatic effect was most prounounced and prolonged when 200 microgram/kg b...

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Bibliographic Details
Published inResearch in experimental medicine Vol. 172; no. 2; p. 131
Main Authors Wetterlin, S, Ahlgren, I, Aronsen, K F, Mulder, J F
Format Journal Article
LanguageEnglish
Published Germany 01.06.1978
Subjects
Animals
Gastric Mucosa - injuries
Gastrointestinal Hemorrhage - therapy
Hemostasis - drug effects
Injections, Intravenous
Rats
Vasopressins - administration & dosage
Vasopressins - analogs & derivatives
Vasopressins - therapeutic use
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Summary:The haemostatic effect of triglycylvasopressin (TGLVP) on the gastric mucosa was evaluated in an experimental model in the rat. TGLVP was found to reduce the bleeding significantly compared with the untreated controls. The haemostatic effect was most prounounced and prolonged when 200 microgram/kg b.w. was given intravenously. The clinical application of this finding is discussed.
ISSN:0300-9130
DOI:10.1007/BF01851403