Metiamide: more than an H2-receptor antagonist

The effect of metiamide on acid secretion and calcium uptake by the frog gastric mucosa was tested alone and in combination with histamine, pentagastrin, aminophylline, and dibutyrl cyclic AMP (db cAMP). Metiamide inhibited all stimulants including db cAMP which presumably acts intracellularly beyon...

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Bibliographic Details
Published inAmerican journal of digestive diseases Vol. 23; no. 2; p. 169
Main Authors Simay, D A, Peskin, G W, Saik, R P
Format Journal Article
LanguageEnglish
Published United States 01.02.1978
Subjects
Animals
Anura
Calcium Radioisotopes
Cyclic AMP - antagonists & inhibitors
Gastric Juice - metabolism
Gastric Mucosa - drug effects
Metiamide - pharmacology
Rana pipiens
Thiourea - analogs & derivatives
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Summary:The effect of metiamide on acid secretion and calcium uptake by the frog gastric mucosa was tested alone and in combination with histamine, pentagastrin, aminophylline, and dibutyrl cyclic AMP (db cAMP). Metiamide inhibited all stimulants including db cAMP which presumably acts intracellularly beyond the H2 receptor. Metiamide, therefore, actively inhibits at a point within the cell beyond the adenylated cyclase membrane receptor complexes. Metiamide also increases calcium influx into the parietal cell, suggesting yet another possible mechanism of inhibition.
ISSN:0002-9211
DOI:10.1007/BF01073195