Indirect evidence for presynaptic location of opiate receptors on chemosensitive primary sensory neurones

1. Rats were pretreated with 50 mg/kg s.c. capsaicin or solvent on the second day of life; 5 months later 3H-diprenorphine binding to homogenates of the whole spinal cord or of the upper dorsal horn of the spinal cord was investigated. 2. Capsaicin pretreatment resulted in a 17% decrease of opiate b...

Full description

Saved in:
Bibliographic Details
Published inNaunyn-Schmiedeberg's archives of pharmacology Vol. 308; no. 3; p. 281
Main Authors Gamse, R, Holzer, P, Lembeck, F
Format Journal Article
LanguageEnglish
Published Germany 01.09.1979
Subjects
Animals
Animals, Newborn - metabolism
Capsaicin - pharmacology
Diprenorphine - metabolism
In Vitro Techniques
Narcotics - metabolism
Neurons - metabolism
Rats
Receptors, Opioid - drug effects
Receptors, Opioid - metabolism
Spinal Cord - metabolism
Stereoisomerism
Online AccessGet more information

Cover

More Information
Summary:1. Rats were pretreated with 50 mg/kg s.c. capsaicin or solvent on the second day of life; 5 months later 3H-diprenorphine binding to homogenates of the whole spinal cord or of the upper dorsal horn of the spinal cord was investigated. 2. Capsaicin pretreatment resulted in a 17% decrease of opiate binding sites in the whole spinal cord and a 37% decrease in the upper dorsal horn with no change in their affinity. 3. Since neonatal capsaicin pretreatment causes degeneration of chemosensitive primary sensory neurones it is concluded that some opiate receptors are located presynaptically on the central terminals of these neurones.
ISSN:0028-1298
DOI:10.1007/BF00501394