Investigation of Lanolin Lipid-Based Nanoparticles as Carriers for Avobenzone

The aim of this study is to develop and characterize lanolin lipid-based nanoparticles as carriers for avobenzone. Solid Lipid nanoparticles (SLNs) were prepared by the high-pressure homogenization technique. The influence of emulsifiers, avobenzone content in lipid (0–20 wt.%), solid lipid blends’...

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Bibliographic Details
Published inNano LIFE Vol. 10; no. 4; p. 2040011
Main Authors Hu, Guangxia, Yin, Hui, Li, Chunxiang, Ng, Suxiu, Yin, Xi Jiang, Hao, Gong
Format Journal Article
LanguageEnglish
Published Hackensack World Scientific Publishing Company 01.12.2020
World Scientific Publishing Co. Pte., Ltd
Subjects
Dispersions
Dynamic stability
Emulsifiers
Investigations
Lanolin
Lecithin
Light scattering
Lipids
Mixtures
Nanoparticles
Photon correlation spectroscopy
Structural stability
X-ray diffraction
Avobenzone
high pressure homogenization
stability
solid lipid nanoparticles
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Summary:The aim of this study is to develop and characterize lanolin lipid-based nanoparticles as carriers for avobenzone. Solid Lipid nanoparticles (SLNs) were prepared by the high-pressure homogenization technique. The influence of emulsifiers, avobenzone content in lipid (0–20 wt.%), solid lipid blends’ composition and dispersions’ solid content on nanoparticles size, zeta potentials, PI value, stability, matrix structure and UV absorption were investigated. The matrix structure of the lipids and the blends was investigated by using X-ray diffraction (XRD) techniques. The particle sizes were ∼ 200 nm and PI values are below 0.25 after production. The stability of lipid nanoparticles (LNs) was characterized by naked eye and dynamic light scattering (DLS) technique. The optimized lipid is the lanolin nanostructured lipid carrier with lecithin and APG 810 as co-emulsifiers.
ISSN:1793-9844
1793-9852
DOI:10.1142/S1793984420400115