A case of alcoholic liver cirrhosis with small hepatocellular carcinoma in ademonatous hyperplasia

• Published in: Kanzo Vol. 34; no. 11; pp. 910 - 916
• Main Authors: FUJIOKA, Hiromichi, OGASAWA, Makoto, AONUMA, Hiromi, MIYAZAKI, Michikazu, YAMADA, Masanobu, TAKASE, Kojiro, NAKANO, Takeshi, TAMEDA, Yukihiko, KOSAKA, Yoshitane
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Hepatology 1993
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.34.910

A 31-year-old male who had taken about 200g of alcohol daily for last 10 years was admitted with jaundice, ascites and encephalopathy on Feb. 7'88. Alcoholic liver cirrhosis was strongly suspected from the laboratory findings and graphic study. Virological study revealed HBsAg, anti-HBc and anti-HCV were negative. Abdominal ultrasonography documented hypoechoic round lesion in left lobe. Laparoscopic findings of the liver was micronodular liver without liver tumor. Target biopsy specimen of hypoechoic lesion did not show any malignancy. 6 months later, the number of hypoechoic lesions increased to 3 in left and 1 in right lobe. Aspiration liver biopsy specimens of hypoechoic lesion in left lobe did not show any malignancy but adenomatous hyperplasia. On Oct. 10'89, this patient was admitted bacause of massive cerebral bleeding and died 7 days later. Autopsy findings of the liver documented that there was a small hepatocellular carcinoma in an adenomatous hyperplasia. Histology revealed thin trabecular pattern (grade II of Edmondson's classification). This case might be indicative of development of hepatocellular carcinoma from adenomatous hyperplasia.